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Showing posts from August, 2012

THE CLASSIC STAGES OF CLINICAL INFECTIONS

As the body of the host responds to the invasive and toxigenic activities of a parasite, it passes through four distinct phases of infection and disease: the incubation period, the prodromium, the period of invasive, and the convalescent period.             The incubation period the time form initial contact with the infectious agent to the appearance of the first symptoms. During the incubation period, the agent is multiplying at the portal of entry but has not yet caused enough damage to elicit symptoms. Although this period is relatively well defined and predictable for each microorganism, it does vary according to host resistance, degree of virulence, and distance between the target organ and the portal of entry (the farther apart, the longer the incubation period). Overall, an incubation period can range from several hours in pneumonic plaque to several years in leprosy. The majority of infections, however,...

A POSITIVE VIEW OF VIRUSES

            Looking at this beautiful tulip, one would never guess that it derives its pleasing appearance from a viral infection. It contains tulip mosaic virus, which affect the development of the plant cells and causes complex patterns of colors in the petals. Aside from this, the virus does not cause severe harm to the plants. Despite the reputation of viruses as cell killers, there is another side of viruses – that of being harmless, and in some cases, even beneficial.             Although there is no agreement on the origins of viruses, it is highly likely that they have been in existence for billions of years. Virologists are convinced that viruses have been an important force in the evolution of living things. This is based on the fact that they interact with the genetic material of their host cells and that they carry genes from on host to another (transduction)...

THE SERENDIPITY OF THE SCIENTIFIC METHOD: DISCOVERING DRUGS

The discoveries in science are not always determined by the strict formulation and testing of a formal hypothesis. Quite often, they involve serendipity and the luck of being in the right place and time, followed by a curiosity and willingness to change the direction of an experiment. This is especially true in the field of drug discoveries. The first antibiotic, penicillin, was discovered in the late 1920s by Dr. Alexander Fleming, who found a mold colony growing on a culture of bacteria that was wiping out the bacteria. He isolated the active ingredient that eventually launched the era of antibiotics. The search for new drugs to treat infections and cancer has been a continuous focus since that time. Even though the detailed science of testing a drug and working out its chemical structure and action required sophisticated scientific technology, the first and most important part of discovery often lies in a keen eye and an open mind.      ...