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The Classic Stage of Clinical Infections

As the body of the host responds to the invasive and toxigenic activities of a parasite, it passes through four distinct phases of infection and disease: the incubation period, the prodromium, the period of invasion, and the convalescent period.
The incubation period is the time initial contact with the infectious agent (at the portal of entry) to the appearance of the first symptoms. During the incubation period period the agent is multiplying at the portal of entry but has not yet caused enough damage to elicit symptoms. Although this period is relatively well defined and predictable for each microorganism, it does vary according to host resistance, degree of virulence, and distance between the target organ and the portal of entry (the farther apart, the longer the incubation period). Overall, an incubation period can range from several hours in pneumonic plague to several years in leprosy. The majority of infections, however, have incubation periods ranging between 2 and 30 days.
The earliest notable symptoms of infection appear as a vague feeling of discomfort, such as head and muscle aches, fatigue, upset stomach, and general malaise. This short period (1-2days) is known as the prodromal stage. The infectious agent next enters a

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